Ramarak had grown to be the largest of the Skull Crawlers on Skull Island. For centuries, the war between Kong's species and the Skull Crawlers raged on until the ape. Kong's parents engaged Ramarak in battle but were brutally slaughtered by Ramarak. This tragedy would lead to Kong having to fend for himself over the next decades an take the responsibility of subding the Skull Crawler population into his own hands. Sometime after the demise of Kong's parents, Ramarak was rendered dormant.
Later, Ramarak took advantage of Kong's weakened state at the hands of Preston Packard and awakened with a screech. He initially had his attention on Packard, but Kong crushed Packard to death with his fist. Ramarak engaged Kong in battle for a brief moment before deciding to pursue the remaining humans. When Cole attempted to sacrifice himself in an attempt to kill Ramarak and allow the group to escape, Ramarak was fooled and swiped Cole into a cliff with his tail, killing him. Kong appeared shortly afterward and engaged Ramarak. As the two fought to the death. Ramarak was able to subdue kong as Kong was tangled in chains from numerous shipwrecks. Before Ramarak could kill Kong, Mason Weaver launched a flare at Ramarak left eye, blinding him slightly. As the other humans stalled Ramarak, Kong recovered and used to propeller as a weapon to overpower Ramarak before slicing his throat open, seemingly killing him. However, Ramarak wasn't killed and wrapped his tongue around Kong's arm in an attempt to devour Weaver, but Kong ripped out Ramarak's tongue and internal organs, killing Ramarak for good and avenging his parents.