The Queen MUTO was initially undocumented by Monarch, as she was hibernating deep beneath a strip mall in Hoboken, New Jersey. Ghidorah's call awoke her, and she proceeded to attack a nearby city. When Madison Russell activated the ORCA in Boston, Queen MUTO became docile and begun to travel to Boston. She arrived in time to witness Godzilla incinerate Ghidorah's last head, and proceeds to confront the reptilian Titan along with Methuselah, Behemoth, Scylla, and Rodan. Strangely, despite Godzilla being the natural enemy and prey of her species, Queen MUTO submits along with the other Titans, recognizing Godzilla as an Alpha.
Queen MUTO's appearance differs slightly from MUTO 2/Femuto, the female MUTO seen in 2014. Queen MUTO's body is covered in numerous spike-like protrusions that indicate her older age, as well as scars from past battles and mating rituals. These spike-like protrusions may imply that Queen MUTO is beginning to metamorphose into a MUTO Prime.